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Article

Recurrent Copy Number Variants and Psychiatric Outcomes in the Context of Polygenic Scores.

JAMA psychiatry - 1 Aug 2026

Vaez Morteza, Montalbano Simone, Waples Ryan, Dybdahl Krebs Morten, Georgii Hellberg Kajsa-Lotta, Gådin Jesper, Stow Daniel, Holmans Peter, van den Bree Marianne, Børglum Anders D, Helenius Dorte, Werge Thomas, Schork Andrew J, Ingason Andrés

Abstract excerpt

Importance: Although both recurrent copy number variants (rCNVs) and polygenic scores (PGSs) impart risk for psychiatric disorders, it remains unclear how they contribute jointly to this risk. Objective: To estimate and compare absolute risk of psychiatric disorders associated with rCNVs and PGSs, independently and jointly. Design, Setting, and Participants: This genetic association study applied data from the...

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Identifiers

PMID: 42201728
DOI: 10.1001/jamapsychiatry.2026.1064
PMCID: PMC13217261

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