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Article

Differential Evolution of Achromobacter spp. Isolates in Upper and Lower Airways of People with Cystic Fibrosis.

Pathogens (Basel, Switzerland) - 22 Apr 2026

Veschetti Laura, Sandri Angela, Saitta Giulia Maria, Boaretti Marzia, Melotti Paola, Cigana Cristina, Bragonzi Alessandra, Lleò Maria M, Malerba Giovanni, Signoretto Caterina

Abstract excerpt

Achromobacter spp. are opportunistic pathogens in people with cystic fibrosis (PwCF), yet the role of the upper airways in their persistence and adaptation remains poorly understood. We investigated whether the sinonasal compartment may act as reservoir and evolutionary niche for Achromobacter spp. during airway infection. Twenty-two isolates obtained from paired nasal lavage and sputum samples of seven PwCF were...

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Identifiers

PMID: 42198579
DOI: 10.3390/pathogens15050452
PMCID: PMC13209813

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