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Triple-Marker Screening of 20 Terpenes Identifies Candidate Modulators of Senescence-Associated Phenotypes in D-Galactose-Treated Endothelial Cells.

Molecules (Basel, Switzerland) - 11 May 2026

Almeida Arthur José Pontes Oliveira de, Pontes Larisse Virgolino da Silva, Souza Júnior Javanyr Frederico de, Soares Evyllen Myllena Cardoso, Santos Adhonias Correia Dos, Gonçalves Tays Amanda Felisberto, Feitosa Mathania Silva de Almeida, Veras Robson Cavalcante, Barbosa Filho Jose Maria, Lesniewski Lisa A, Donato Anthony J, Medeiros Isac Almeida de

Abstract excerpt

Aging is a major risk factor for chronic diseases, including cardiovascular diseases. Endothelial cells (ECs) are particularly vulnerable to age-related stress, and endothelial senescence contributes to vascular aging. In the present study, we applied a triple-screening strategy to identify terpenes that modulate senescence-associated phenotypes in endothelial cells. Rat aortic endothelial cells (RAECs) were...

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beta-Galactosidase
Biomarkers
Cell Survival
Cellular Senescence

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Endothelial Cells

Oxidative Stress

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PMID: 42197166
DOI: 10.3390/molecules31101614
PMCID: PMC13209231

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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