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Chemically Defined Medium Enables GDNF-Driven Early Neuronal-like Phenotype of Human Dental Pulp Stem Cells.

Cells - 21 May 2026

Silva-Lucero Maria-Del-Carmen, Lopez-Toledo Gustavo, Cortés-Morales Víctor-Adrián, Montesinos Juan-José, Sampieri-Cabrera Raúl, García David-E, Padilla-Mendoza Juan-Ramon, Lora-Marin Obed-Ricardo, Buendia-Meraz Jesus-Adrian, Jiménez-Orozco Fausto-Alejandro, López-Reyes Israel, Mondragon-Teran Paul, Cardenas-Aguayo Maria-Del-Carmen

Abstract excerpt

BACKGROUND: Human dental pulp stem cells (hDPSCs) are a promising source of multipotent mesenchymal stem cells (MSCs) for regenerative neurology because of their inherent neurogenic potential. However, robust and reproducible protocols for driving their terminal neuronal maturation in a fully defined, xeno-free environment are lacking. METHODS: hDPSCs were isolated from a donor tooth and characterized for...

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Identifiers

PMID: 42193962
DOI: 10.3390/cells15100953
PMCID: PMC13204485

Genes

GDNF
BDNF
SOX2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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