Genome-wide association study reveals a novel tuberculosis susceptibility locus in multiple East Asian and European populations.

doi:10.1186/s13073-026-01670-6

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Genome-wide association study reveals a novel tuberculosis susceptibility locus in multiple East Asian and European populations.

Genome medicine - 27 May 2026

Chang Xuling, Li Zheng, Thai Phan Vuong Khac, Ha Dang Thi Minh, Thuong Nguyen Thuy Thuong, Wee Denise, Subhan Alya Sufiyah Binte Mohamed, Silcocks Matthew, Chee Cynthia Bin Eng, Nhu Nguyen Thi Quynh, Heng Chew-Kiat, Teo Yik Ying, Singhal Amit, Oehlers Stefan H, Yuan Jian-Min, Koh Woon-Puay, Caws Maxine, Khor Chiea Chuen, Dorajoo Rajkumar, Dunstan Sarah J

Abstract excerpt

BACKGROUND: Tuberculosis (TB) continues to be a leading cause of morbidity and mortality worldwide. Although numerous genome-wide association studies (GWAS) have explored TB susceptibility across various ethnic groups, multi-population replication of findings has been very limited, particularly outside the HLA region, and a significant portion of TB heritability remains unexplained. METHODS: We conducted GWAS in...

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PMID: 42192477
DOI: 10.1186/s13073-026-01670-6
PMCID: PMC13214086

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