Elevated microbially-derived metabolites in autism: a possible diagnostic screening test for a distinct ASD phenotype.

doi:10.1038/s41380-026-03620-5

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Elevated microbially-derived metabolites in autism: a possible diagnostic screening test for a distinct ASD phenotype.

Molecular psychiatry - 1 Sept 2026

Flynn Christina K, Carr Kevin, Whiteley Paul, Nirmalkar Khemlal, Bellinghiere Andrew, Hahn Juergen, Liu Hongbin, Arici Halil, Hewitson Laura, Devlin Morgan, Pollard Elena L, Pathak Khyatiben V, Garcia Mansfield Krystine, Rosales Torres Anakaren, Pirrotte Patrick, Kalb Daniel B, Keen Rebekah, Kenyon Victoria, Fasano Alessio, Krajmalnik-Brown Rosa, Adams James B, Kadzielski Sarah

Abstract excerpt

Many studies have confirmed that a subset of children with autism spectrum disorder (ASD) have unusually high urinary concentrations of microbially-derived metabolites (MDMs) such as p-cresol sulfate and indoxyl sulfate. We hypothesized that these MDMs may affect neurodevelopment through the gut-brain axis and that a sub-phenotype characterized by gut dysbiosis may be present in most ASD individuals. This...

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PMID: 42192173
DOI: 10.1038/s41380-026-03620-5
PMCID: PMC13441887

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