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Article

Association between creatinine-to-cystatin C ratio and ALSFRS-R across clinical phenotypes.

BMC neurology - 25 May 2026

Fujiwara Yoshihisa, Hashiguchi Akihiro, Yamashiro Shiori, Seno Hiroshi, Ohya Yuichiro, Yasutomi Daigo, Fujisaki Natsumi, Kido Miwako, Suwazono Shugo, Tokashiki Takashi

Abstract excerpt

BACKGROUND: Reliable and accessible biomarkers for amyotrophic lateral sclerosis (ALS) are scarce. Creatinine (Cre) reflects muscle mass, whereas cystatin C (CysC) may reflect neurodegeneration without being directly influenced by muscle mass; however, both have limitations. We aimed to investigate whether the creatinine-to-cystatin C ratio (Cre/CysC) was cross-sectionally associated with functional status in...

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Identifiers

PMID: 42185781
DOI: 10.1186/s12883-026-04983-6
PMCID: PMC13377769

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