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Article

Disruption of carotenoid metabolism in cavefish via loss of beta-carotene oxygenase 2a.

Current biology : CB - 8 Jun 2026

Guerra David Peréz, Bandara Sepalika, Leal Francisca, Vasquez-Gross Hans, Petereit Juli, von Lintig Johannes, Riddle Misty R

Abstract excerpt

Vitamin A is an essential micronutrient that supports vision, immunity, and development, yet excess vitamin A can be toxic. Most vertebrates maintain tightly regulated vitamin A levels by cleaving dietary carotenoids into retinoids via specialized enzymes, including the carotenoid oxygenase Bco2. To what extent genetic changes in carotenoid-metabolism enzymes such as Bco2 drive natural variation in vitamin A...

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Identifiers

PMID: 42184829
DOI: 10.1016/j.cub.2026.05.003
PMCID: PMC13215598

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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