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Article

A Splicing Mutation in mitfa is Involved in the Depigmentation of Cavefish Triplophysa rosa.

Molecular biology and evolution - 30 Jul 2025

Zhang Mingming, Zhao Qingshuo, Huang Jinqing, Zou Ming, Guo Baocheng, Zhao Yahui, Meng Fanwei

Abstract excerpt

Regression traits such as pigmentation loss in cave-dwelling species offer powerful models for understanding evolutionary mechanisms under extreme environments. In this study, we investigated the genetic and evolutionary mechanisms underlying pigmentation loss in the cavefish Triplophysa rosa, a depigmented, eyeless species endemic to subterranean habitats. Compared with its surface-dwelling relative T. stenura,...

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Topics

Animals
Pigmentation
Zebrafish
Microphthalmia-Associated Transcription Factor
Fish Proteins
RNA Splicing

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Mutation

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Identifiers

PMID: 40709436
DOI: 10.1093/molbev/msaf175
PMCID: PMC12343024

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