Article
Genome-wide analysis of cis-regulatory changes underlying metabolic adaptation of cavefish.
Nature genetics - 1 May 2022
Krishnan Jaya, Seidel Chris W, Zhang Ning, Singh Narendra Pratap, VanCampen Jake, Peuß Robert, Xiong Shaolei, Kenzior Alexander, Li Hua, Conaway Joan W, Rohner Nicolas
Abstract excerpt
Cis-regulatory changes are key drivers of adaptative evolution. However, their contribution to the metabolic adaptation of organisms is not well understood. Here, we used a unique vertebrate model, Astyanax mexicanus-different morphotypes of which survive in nutrient-rich surface and nutrient-deprived cave waters-to uncover gene regulatory networks underlying metabolic adaptation. We performed genome-wide...
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