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Article

Cytokine receptor and JAK/STAT pathway mutations in acute myeloid leukemia: Prevalence and clinical impact.

Cancer - 1 Jun 2026

Albliwi Moath, Nurse Daniel P, Zabor Emily C, Hanna John, El-Asmar Jessica, Bawwab Ameed, Abuamsha Hasan, Abu-Farsakh Yomna, Batah Heya, Rauf Asad, Nakitandwe Joy, Bosler David S, Parthasarathy Prerana Bangalore, Alban Tyler, Jain Akriti G, Molina John C, Balderman Sophia, Singh Abhay, Gerds Aaron T, Mukherjee Sudipto, Advani Anjali S, Carraway Hetty E, Mustafa Ali Moaath K

Abstract excerpt

BACKGROUND: Mutations in cytokine receptor and JAK/STAT; Cy-JAK/STAT) signaling genes drive myeloproliferative neoplasms (MPNs) but remain incompletely characterized in acute myeloid leukemia (AML). The authors evaluated the prevalence, clinical presentation, and prognostic significance of Cy-JAK/STAT pathway mutations in patients with AML and compared outcomes across disease ontogeny. METHODS: In total, 971...

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Identifiers

PMID: 42175603
DOI: 10.1002/cncr.70465

Genes

JAK2
CALR
MPL
JAK1
JAK3
SH2B3
STAT3
STAT5B

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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