Three Mycobacterium avium genotypes classified by 1.4-Mb genomic inversion and single-nucleotide variations are tightly linked to disease progression.

doi:10.1016/j.ijid.2026.108816

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Article

Three Mycobacterium avium genotypes classified by 1.4-Mb genomic inversion and single-nucleotide variations are tightly linked to disease progression.

International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases - 1 Aug 2026

Tanaka Kentaro, Bamba Yuuki, Aoki Nobumasa, Yamagishi Ikumi, Shima Kenjiro, Ogata Hideyuki, Shibata Satoshi, Ohshima Yasuyoshi, Watanabe Satoshi, Moro Hiroshi, Koya Toshiyuki, Yamada Mitsuhiro, Sugiura Hisatoshi, Watanabe Akira, Kikuchi Toshiaki

Abstract excerpt

INTRODUCTION: Mycobacterium avium lung disease (MA-LD) poses significant challenges in predicting disease progression. This study aimed to characterize the genomic diversification of M. avium and define its relationship to disease progression. METHODS: We investigated the whole-genome sequence data of 36 M. avium clinical strains. Comparative analyses of genomic structure and sequence were undertaken between...

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PMID: 42167536
DOI: 10.1016/j.ijid.2026.108816

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