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Article

Genomic characterisation of recurrent Mycobacterium avium isolates from chronically infected patients reveals patterns of within-host evolution.

Genome medicine - 13 Oct 2025

Walsh Aaron M, Roycroft Emma, Hinchion Kate, Basdeo Sharee A, Sheedy Frederick J, Crispie Fiona, Cotter Paul D, McLaughlin Anne Marie, Keane Joseph, Fitzgibbon Margaret M, Gleeson Laura E

Abstract excerpt

BACKGROUND: Mycobacterium avium complex causes chronic and difficult-to-treat infection in vulnerable patient groups, and incidence is increasing worldwide. Whole genome sequencing has the potential to reveal new information about how M. avium persists over time in the human lung. METHODS: We analysed the genomes of 287 isolates of M. avium that were sampled longitudinally from 56 patients. Our dataset included...

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Identifiers

PMID: 41084085
DOI: 10.1186/s13073-025-01549-y
PMCID: PMC12516842

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