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Article

Placental lipid droplets and histone marks reveal a metabolic-epigenetic phenotype in the BTBR mouse model of autism.

Placenta - 24 Jun 2026

Viscomi Maria Pia, Ziętek Marta Marlena, Winiarczyk Dawid, Sampino Silvestre

Abstract excerpt

INTRODUCTION: The placenta shapes fetal brain development through metabolic and epigenetic regulation. The BTBR T+ Itpr3tf/J (BTBR) mouse provides a valuable model of neurodevelopmental vulnerability. This study investigates the cellular and spatial distribution of lipid metabolic and epigenetic alterations within the BTBR placenta. METHODS: We analyzed mid-gestation (12.5 days post coitum) placentas from BTBR...

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Identifiers

PMID: 42167047
DOI: 10.1016/j.placenta.2026.05.020

Genes

PLA2G4E

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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