Article
Performance of the permutation test approach with base calling errors for detecting changes in variant allele frequencies in ctDNA for a single patient.
Statistical applications in genetics and molecular biology - 1 Jan 2026
Kuchiba Aya, Nishino Jo, Yachida Shinichi, Sunami Kuniko, Koyama Takafumi, Yamamoto Noboru, Kato Mamoru, Shibata Taro
Abstract excerpt
Serial measurements of circulating tumor DNA (ctDNA) with next-generation sequencing (NGS) technology enable the real-time, noninvasive evaluation of longitudinal changes of molecular profiles in tumor tissues. These profiles can assist in monitoring disease progression and tumor response to targeted therapies, thereby facilitating informed therapeutic decision making through precise molecular characterization....
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