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Article

Overlapping expression and co-operative function of the zebrafish pcdh15 paralogs.

Communications biology - 18 May 2026

Chrystal Paul W, Kuzmanova Lisa, Liu Jingpin, Izvorean Alexa, Majeed Ishmael, Tjoenardi Jefferson F, Lin Qian, Tropepe Vincent

Abstract excerpt

With orthologs for >70% of human genes, zebrafish represent a popular model for investigating development and disease, particularly when murine models are unsuitable. One caveat of zebrafish genetic models is the prevalence of paralogs, where compensation and transcriptional adaptation can complicate our understanding. Usher syndrome type 1 F (USH1F), caused by PCDH15 mutations, exemplifies the need for...

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Identifiers

PMID: 42151386
DOI: 10.1038/s42003-026-10289-7
PMCID: PMC13443151

Genes

CP
PCDH15

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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