Joint clinical and molecular subtyping of COPD with variational autoencoders.

Abstract excerpt

Chronic Obstructive Pulmonary Disease (COPD) is a complex, heterogeneous disease. Traditional subtyping methods generally focus on either the clinical manifestations or the molecular endotypes of the disease, leading to classifications that only partially reflect disease heterogeneity. Here, we introduce a variational autoencoder-based subtyping pipeline that jointly embeds clinical and gene expression data into...

Topics

• Humans
• Pulmonary Disease, Chronic Obstructive
• Autoencoder
• Phenotype
• Gene Expression Profiling
• Smoking