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Low Dose Amitriptyline-Induced Electrical Storm Unmasking a Novel SCN5A and KCNQ1 Compound Genotype: Insights from Family Cascade Screening.

Cardiovascular toxicology - 13 May 2026

Vo Thai Duy, Kieu Ngoc Dung, Tran Le Uyen Phuong, Van Khanh Nguyen Thi, Nguyen Tri Thuc, Lo Li-Wei, Dao Thi Thanh Binh

Abstract excerpt

Cardiac toxicity from QT-prolonging drugs can precipitate malignant ventricular arrhythmias in susceptible individuals, and family screening may clarify inherited risk. We report a 33-year-old woman with a history of postpartum cardiac arrest treated with a secondary-prevention implantable cardioverter-defibrillator (ICD) who developed an electrical storm after self-administration of a single low dose of...

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Source

Identifiers

PMID: 42126717
DOI: 10.1007/s12012-026-10125-8

Genes

KCNQ1
SCN5A

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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