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Phylogenetic and genome-wide analysis of codon usage reveals geographic and host-specific adaptation in Vaccinia virus.

Archives of virology - 12 May 2026

Iqbal Hafsa, Ahmad Faisal, Ahmad Sajjad, Ahmad Iftikhar, Qadir Muhammad Yar Sobhan, Khalid Ali, Ashraf Zurva, Ahmad Zohra, Zouidi Ferjeni

Abstract excerpt

Vaccinia virus (VACV) is a member of the Poxviridae family and served as the vaccine strain used to eradicate smallpox. As a large double-stranded DNA virus, VACV exhibits a broad host range and remains a model organism for studying viral evolution and gene expression. Codon usage bias (CUB) is a fundamental feature of genome evolution that reflects the interplay between mutational pressure and natural selection....

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 42115427
DOI: 10.1007/s00705-026-06643-z

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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