Article
Genomic analysis of codon usage shows influence of mutation pressure, natural selection, and host features on Marburg virus evolution.
BMC evolutionary biology - 26 Aug 2015
Nasrullah Izza, Butt Azeem M, Tahir Shifa, Idrees Muhammad, Tong Yigang
Abstract excerpt
BACKGROUND: The Marburg virus (MARV) has a negative-sense single-stranded RNA genome, belongs to the family Filoviridae, and is responsible for several outbreaks of highly fatal hemorrhagic fever. Codon usage patterns of viruses reflect a series of evolutionary changes that enable viruses to shape their survival rates and fitness toward the external environment and, most importantly, their hosts. To understand...
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