Article
Orthogonal viability assays and high-content phenotyping identify enhanced cytotoxicity of SLN-pDNA complexes and heightened sensitivity in PC-3 cells.
Toxicology in vitro : an international journal published in association with BIBRA - 1 Aug 2026
Moraes-Lacerda Thaís, Garcia-Fossa Fernanda, de Jesus Marcelo Bispo
Abstract excerpt
Solid lipid nanoparticles (SLNs) have emerged as a versatile platform for the intracellular delivery of therapeutic molecules being widely used in drug and gene delivery owing to their biocompatibility, scalability, and long-term stability. Despite their favorable safety profile, SLN-cell interactions are not necessarily biologically inert, particularly when SLNs are complexed with biomolecules such as plasmid...
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