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Article

MHC-I alleles mediate clearance and antibody response to the zoonotic Lassa virus in Mastomys rodent reservoirs.

PLoS neglected tropical diseases - 1 Feb 2024

Olayemi Ayodeji, Schmid Dominik Werner, Fleischer Ramona, Wilhelm Kerstin, Heni Alexander Christoph, Mueller-Klein Nadine, Haikukutu Lavinia, Fichet-Calvet Elisabeth, Günther Stephan, Sommer Simone

Abstract excerpt

West African Mastomys rodents are the primary reservoir of the zoonotic Lassa virus (LASV). The virus causes haemorrhagic Lassa fever and considerable mortality in humans. To date, the role of Mastomys immunogenetics in resistance to, and persistence of, LASV infections is largely unknown. Here, we investigated the role of Major Histocompatibility Complex class I (MHC-I) on LASV infection status (i.e., active vs....

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Identifiers

PMID: 38421939
DOI: 10.1371/journal.pntd.0011984
PMCID: PMC10903922

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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