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Article

Adult hippocampal neural stem and progenitor cells regulate the neurogenic niche by secreting VEGF.

Proceedings of the National Academy of Sciences of the United States of America - 31 Mar 2015

Kirby Elizabeth D, Kuwahara Akela A, Messer Reanna L, Wyss-Coray Tony

Abstract excerpt

The adult hippocampus hosts a population of neural stem and progenitor cells (NSPCs) that proliferates throughout the mammalian life span. To date, the new neurons derived from NSPCs have been the primary measure of their functional relevance. However, recent studies show that undifferentiated cells may shape their environment through secreted growth factors. Whether endogenous adult NSPCs secrete functionally...

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Identifiers

PMID: 25775598
DOI: 10.1073/pnas.1422448112
PMCID: PMC4386397

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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