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Article

TGM2-TUFM promotes acquired resistance to EGFR-TKIs in EGFR-mutated NSCLC through p62-mediated lipophagy.

Respiratory research - 9 May 2026

Shen Jie, Gou Lanying, Sun Yujie, Luo Peng, Hong Shuo, Zhang Chunyan, Sun Yueqin, Shen Weitao, Fang Jianbo, Zhang Yueming, Li Xuechun, Ying Haoxuan, Lyu Qiong, Zhang Jian, Wei Ting

Abstract excerpt

BACKGROUND: Acquired resistance to epidermal growth factor receptor-tyrosine kinase inhibitors (EGFR-TKIs) remains the leading cause of treatment failure in advanced non-small cell lung cancer (NSCLC) patients harboring sensitizing EGFR mutations. This study aims to investigate the underlying resistance mechanisms in EGFR-mutated NSCLC. METHODS: Analyze the differential genes in the transcriptome sequencing data...

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Source

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Identifiers

PMID: 42106683
DOI: 10.1186/s12931-026-03665-8
PMCID: PMC13330442

Genes

EGFR
TGM2
TUFM
CCK
PLIN2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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