Article
Abnormal Amyloidogenesis Identified in Plasma of Patients with Spinocerebellar Ataxia Type 12.
Cerebellum (London, England) - 9 May 2026
Banerjee Rebecca, Sengupta Swarnava, Rungta Jyoti, Ansari Sabbir, Banerjee Sattwika, Biswas Bishmita, Pal Rakhi, Chattarji Sumantra, Choudhury Supriyo, Kumar Hrishikesh
Abstract excerpt
Spinocerebellar ataxia type 12 (SCA12), a progressive neurological disorder, is the second-most common autosomal dominant ataxia in India. The disease is clinically heterogeneous with a variable age-of-onset. A CAG repeat expansion mutation upstream of PPP2R2B gene is causal to SCA12 motor and non-motor symptoms but its pathophysiological significance remains unknown. PPP2R2B encodes for the regulatory subunit B...
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