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Article

Pharmacogenetic of voriconazole antifungal agent in pediatric patients.

Pharmacogenomics - 1 Jul 2018

Allegra Sarah, Fatiguso Giovanna, Francia Silvia De, Pirro Elisa, Carcieri Chiara, Cusato Jessica, Nicolò Amedeo De, Avataneo Valeria, Perri Giovanni Di, D'Avolio Antonio

Abstract excerpt

AIM: We explored the role of SNPs within the SLCO1B3, SLCO1B1, SLC22A6, ABCB1, ABCG2, SLCO3A1, CYP2C19, ABCC2, SLC22A1, ABCB11 and NR1I2 genes on voriconazole pharmacokinetics. PATIENTS & METHODS: 233 pediatric patients were enrolled. Drug plasma Ctrough was measured by a HPLC-MS method. Allelic discrimination was performed by qualitative real-time PCR. RESULTS: SLCO1B3 rs4149117 c.334 GT/TT (p = 0.046), ABCG2...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 29914286
DOI: 10.2217/pgs-2017-0173

Genes

ABCB1
ABCC2
ABCG2
ABCB11

Provenance

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