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Article

BRCA2 and NF2-Mutated High-Grade Renal Cell Carcinoma: A Case Report and Literature Review.

International journal of surgical pathology - 1 Aug 2026

Talafha Muna M, Ligon John A, Henegan John C, Manucha Varsha

Abstract excerpt

Breast cancer susceptibility gene 2 (BRCA2) and neurofibromatosis type 2 (NF2) are key tumor suppressor genes involved in homologous recombination repair of DNA double-strand breaks and various signaling pathways, respectively. While BRCA2 and NF2 mutations are well-established in many solid tumors, their role in renal cell carcinoma (RCC) remains unclear. We describe a 60-year-old African American man with a...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 41731704
DOI: 10.1177/10668969251407312

Genes

BRCA2
NF2
FH
SMARCB1
AMACR
KRT7
PAX8

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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