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Article

The polygenic score for age at menopause is independently associated with the response of controlled ovarian hyperstimulation in women undergoing IVF.

EBioMedicine - 1 May 2026

van Zwol-Janssens Charissa, Lamballais Sander, Loehrer Elizabeth A, Laven Joop S E, Kleefstra Tjitske, Louwers Yvonne V

Abstract excerpt

BACKGROUND: While Anti-Müllerian hormone (AMH) helps personalise In Vitro Fertilization (IVF) stimulation protocols, a significant number of women still do not achieve an optimal ovarian response. To address this, we explore the utility of a polygenic score for age at natural menopause (ANM) as a predictor for ovarian response during IVF. METHODS: This cohort study included 435 women who underwent standardised...

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Identifiers

PMID: 42066436
DOI: 10.1016/j.ebiom.2026.106267
PMCID: PMC13145881

Genes

AMH

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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