Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Concentration dependency of an acyl glucuronide metabolite in eltrombopag-induced hepatotoxicity: Role of UGT1A1 genotype.

British journal of clinical pharmacology - 1 Aug 2026

Oda Shun, Doki Kosuke, Obara Naoshi, Suzuki Yoshiharu, Sakata-Yanagimoto Mamiko, Homma Masato

Abstract excerpt

AIM: Eltrombopag, a thrombopoietin receptor agonist for aplastic anaemia, can cause hepatotoxicity. It is metabolized by uridine diphosphate-glucuronosyltransferase (UGT) 1A1 to form an acyl glucuronide metabolite; however, the relationships among serum concentrations of the acyl glucuronide metabolite, UGT1A1 genotypes and hepatotoxicity remain unclear. METHOD: We examined the serum concentrations of eltrombopag...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Benzoates
Share to Chemical and Drug Induced Liver Injury

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Glucuronides

Share to Glucuronosyltransferase

Share to Hydrazines

Share to Liver Function Tests

Share to Pyrazoles

Share to Receptors, Thrombopoietin

Source

Open in PubMed Open full text

Identifiers

PMID: 42050376
DOI: 10.1002/bcp.70585
PMCID: PMC13420886

Genes

UGT1A1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Concentration dependency of an acyl glucuronide metabolite in eltrombopag-induced hepatotoxicity: Role of UGT1A1 genotype.PMID 42050376Read ↗

Relationship between CYP2C8, UGT1A1, and ABCG2 gene polymorphisms and the exposure, efficacy, and toxicity of eltrombopag in the treatment of refractory aplastic anemia.Semantic proximity Read ↗

Oncology Drug Dosing in Gilbert Syndrome Associated with UGT1A1: A Summary of the Literature.Semantic proximity Read ↗

Gilbert-Meulengracht's syndrome and pharmacogenetics: is jaundice just the tip of the iceberg?Semantic proximity Read ↗

Pharmacokinetics of Eltrombopag in Healthy Chinese Subjects and Effect of Sex and Genetic Polymorphism on its Pharmacokinetic and Pharmacodynamic Variability.Semantic proximity Read ↗

Contribution of human organic anion transporter 3-mediated transport of a major linezolid metabolite, PNU-142586, in linezolid-induced thrombocytopeniaSemantic proximity Read ↗

Thrombopoietin Receptor Agonists (TPO-RAs): Drug Class Considerations for PharmacistsSemantic proximity Read ↗

Application of pharmacogenetics: UGT1A1*28 and nilotinib-induced unconjugated hyperbilirubinaemia in a patient with chronic myeloid leukaemia.Semantic proximity Read ↗

UGT1A1*28 genotype affects the in-vitro glucuronidation of thyroxine in human livers.Semantic proximity Read ↗

Identification of selective inhibitors of uridine 5'-diphospho-glucuronosyltransferase (UGT) 1A3 and UGT1A8 and their application in UGT reaction phenotyping studies in human liver and intestinal microsomes.Semantic proximity Read ↗

Pegvisomant-induced liver injury is related to the UGT1A1*28 polymorphism of Gilbert's syndrome.Semantic proximity Read ↗

Pharmacokinetics, Pharmacodynamics, Pharmacogenomics, Safety, and Tolerability of Avatrombopag in Healthy Japanese and White Subjects.Semantic proximity Read ↗

Hepatotoxicity of oral and intravenous voriconazole in relation to cytochrome P450 polymorphisms.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.