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Pharmacokinetics, Pharmacodynamics, Pharmacogenomics, Safety, and Tolerability of Avatrombopag in Healthy Japanese and White Subjects.

Clinical pharmacology in drug development - 1 Feb 2018

Nomoto Maiko, Pastino Gina, Rege Bhaskar, Aluri Jagadeesh, Ferry Jim, Han David

Abstract excerpt

Avatrombopag, an orally administered, small-molecule thrombopoietin receptor (c-Mpl) agonist, is currently in clinical development for the potential treatment of severe thrombocytopenia in patients with chronic liver disease undergoing an elective procedure. The objectives of this study were to characterize and compare the pharmacokinetics (including the food effect) and pharmacodynamics (platelet count) of...

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PMID: 28339166
DOI: 10.1002/cpdd.349

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