Neutrophils exhibit distinct migration phenotypes that are modulated by transendothelial migration.

doi:10.1038/s42003-026-10122-1

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Article

Neutrophils exhibit distinct migration phenotypes that are modulated by transendothelial migration.

Communications biology - 28 Apr 2026

Schwartz Amy B, Kandasamy Adithan, Tu Yunpeng, de Lecea Alex, Nigam Vishal, Del Álamo Juan C, Yeh Yi-Ting

Abstract excerpt

The extravasation of polymorphonuclear neutrophils (PMNs) is a critical component of the innate immune response that involves transendothelial migration (TEM) and interstitial migration. TEM-mediated interactions between PMNs and vascular endothelial cells (VECs) trigger a cascade of biochemical and mechanobiological signals whose effects on interstitial migration are currently unclear. To address this question,...

Topics

Humans
Neutrophils
Transendothelial and Transepithelial Migration
Phenotype
HL-60 Cells
G-Protein-Coupled Receptor Kinase 2
Endothelial Cells
Cell Movement

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Identifiers

PMID: 42049959
DOI: 10.1038/s42003-026-10122-1
PMCID: PMC13328646

Genes

GRK2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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