Article
Neutrophils exhibit distinct migration phenotypes that are modulated by transendothelial migration.
Communications biology - 28 Apr 2026
Schwartz Amy B, Kandasamy Adithan, Tu Yunpeng, de Lecea Alex, Nigam Vishal, Del Álamo Juan C, Yeh Yi-Ting
Abstract excerpt
The extravasation of polymorphonuclear neutrophils (PMNs) is a critical component of the innate immune response that involves transendothelial migration (TEM) and interstitial migration. TEM-mediated interactions between PMNs and vascular endothelial cells (VECs) trigger a cascade of biochemical and mechanobiological signals whose effects on interstitial migration are currently unclear. To address this question,...
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