Article
Multi-View Transformers for Structure-Aware HA-NA Drift Risk Scoring and Mutation Hotspot Mapping.
Viruses - 30 Mar 2026
Agarwal Pankaj, Yogarayan Sumendra, Sayeed Md Shohel, Tipu Rupesh Kumar
Abstract excerpt
Seasonal influenza A evolves quickly through mutations in haemagglutinin (HA) and neuraminidase (NA), which can reduce vaccine match and lower protection. Many sequence-only models do not link codon-level mutations to three-dimensional (3D) protein context and long-term evolutionary signals within one scoring framework. This study presents TRIAD-Influenza (TRIAD: Token-Residue-Integrated Architecture for Drift),...
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