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HHV-6A Drives Epigenetic Reprogramming via an EZH2-SIRT1 Axis to Sustain Mutant p53 and Reshape Oncogenic Inflammatory Signaling.

Viruses - 26 Mar 2026

Benedetti Rossella, Di Crosta Michele, Stirparo Alessia, Aron George Alexandru, Mardente Stefania, Santarelli Roberta, Gonnella Roberta, Gilardini Montani Maria Saveria, Cirone Mara

Abstract excerpt

We previously demonstrated that human herpesvirus 6A infects papillary thyroid cancer cells (BCPAP), inducing molecular changes compatible with a tumor-promoting phenotype, including increased expression of R273H mutant TP53 (mutp53), upregulation of c-Myc, and enhanced secretion of IL-6. To investigate whether and how epigenetic mechanisms contribute to these virus-induced effects, we examined the histone...

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Share to Enhancer of Zeste Homolog 2 Protein
Share to Epigenesis, Genetic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Herpesvirus 6, Human

Share to Inflammation

Share to Interleukin-6

Share to Proto-Oncogene Proteins c-myc

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Source

Open in PubMed Open full text

Identifiers

PMID: 42043198
DOI: 10.3390/v18040409
PMCID: PMC13120135

Genes

SIRT1
TP53

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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HHV-6A Drives Epigenetic Reprogramming via an EZH2-SIRT1 Axis to Sustain Mutant p53 and Reshape Oncogenic Inflammatory Signaling.PMID 42043198Read ↗

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