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Optimization of Preimplantation Genome Profiling Supports Genomic Selection in Cattle.

Cells - 16 Apr 2026

Yan Shihui, Yan Saina, Cheng Yuanweilu, Cui Hengyuan, Pang Yang, Si Jingfang, Jiang Li, Sun Dongxiao, Pauciullo Alfredo, Lenstra Johannes A, Zeng Shenming, Zhang Yi

Abstract excerpt

Preimplantation embryo genomic selection (eGS) enables selection prior to implantation and could accelerate genetic gain in cattle. A major hurdle is the limited DNA from embryo biopsies, requiring efficient whole-genome amplification (WGA) for accurate genomic analyses. However, alternative WGA methods and genotyping strategies have not been systematically compared in cattle. This study evaluated different...

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PMID: 42041572
DOI: 10.3390/cells15080705
PMCID: PMC13115129

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