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Article

Interferon-Regulatory Factor 4 Is Required Not Only for Induction but Also for Maintenance of the Th17 Phenotype.

European journal of immunology - 1 Apr 2026

Patten Janis, Erramsetti Prema, Olmedo Addi Josua Romero, Pinkenburg Olaf, Huber Magdalena, Lohoff Michael

Abstract excerpt

We previously showed that primary differentiation of naïve T cells is dependent on IRF4. Now we show that maintenance of already differentiated conventional and pathogenic Th17 cells is also dependent on IRF4.

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Identifiers

PMID: 42036789
DOI: 10.1002/eji.70193
PMCID: PMC13111725

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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