Article
Increased remodeling of type XXII collagen is associated with an inflammatory phenotype in Crohn's disease.
Scientific reports - 25 Apr 2026
Alexdottir Marta S, Bourgonje Arno R, Tsapanou-Katranara Thomai, Pehrsson Martin, Godskesen Line E, Loveikyte Roberta, Visschedijk Marijn C, Festen Eleonora A M, Weersma Rinse K, Bay-Jensen Anne-Christine, Karsdal Morten A, Krag Aleksander, Kjeldsen Jens, Dijkstra Gerard, Mortensen Joachim H
Abstract excerpt
In Crohn's disease, extracellular matrix (ECM) dysfunction and loss of tissue integrity are key pathological features. Fibril-associated collagens with interrupted triple helices (FACIT) are known to regulate ECM assembly and mediate biophysical cues in their microenvironment but remain largely understudied. This study aimed to investigate a novel biomarker reflecting remodelling of the FACIT collagen type XXII...
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