Genetic determinants of fatigue up to 2 years after radiotherapy in prostate cancer patients.

doi:10.1038/s41467-026-72041-3

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Article

Genetic determinants of fatigue up to 2 years after radiotherapy in prostate cancer patients.

Nature communications - 22 Apr 2026

Heumann Philipp, Aguado-Barrera Miguel E, Jandu Harkeran K, Azria David, Briers Erik, Bultijnck Renée, Chang-Claude Jenny, Choudhury Ananya, Dunning Alison M, Fachal Laura, Fuentes-Ríos Olivia, Gómez-Caamaño Antonio, Gutiérrez-Enríquez Sara, Kaaks Rudolf, Kerns Sarah L, Lambrecht Maarten, Romero Juan Camilo Rosas, Rosenstein Barry S, De Ruysscher Dirk, Schmidt Martina E, Sperk Elena, Stobart Hilary, Symonds R Paul, Veldeman Liv, Veldwijk Marlon R, Ward Tim, Webb Adam, West Catharine M L, Rancati Tiziana, Rattay Tim, Vega Ana, Talbot Christopher J, Seibold Petra

Abstract excerpt

Fatigue is a common symptom of cancer patients, which can impair quality of life even years after treatment. Little is known about genetic determinants of fatigue, especially in prostate cancer (PCa). This study aims to identify SNPs associated with long-term fatigue in a prospective cohort of PCa patients. A genome-wide association study was conducted in non-metastatic PCa patients treated with radiotherapy in 7...

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PMID: 42020408
DOI: 10.1038/s41467-026-72041-3
PMCID: PMC13102951

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ACTR3

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