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Article

Genetic Modifiers in β-Thalassemia Intermedia: A Study on 102 Iraqi Arab Patients.

Genetic testing and molecular biomarkers - 1 May 2015

Al-Allawi Nasir A S, Puehringer Helene, Raheem Ruzaiqah A, Oberkanins Christian

Abstract excerpt

To determine the molecular basis of β-thalassemia intermedia (TI) and the contribution of the three hemoglobin F (HbF) quantitative trait loci (QTLs) on chromosomes 11, 2, and 6 to the milder phenotype, a total of 102 Iraqi Arab patients with TI were studied. The β and α genotypes as well as HBG2 g. 158 C>T (rs7482144), BCL11A (rs1427407 and rs10189857), and HBS1L-MYB (rs28384513 and rs9399137) by multiplex...

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Topics

Adolescent
Adult
Alleles
Arabs
Child
Child, Preschool
Female
Fetal Hemoglobin
Genetic Association Studies
Humans
Iraq
Male
Middle Aged
Polymorphism, Single Nucleotide
Quantitative Trait Loci
alpha-Thalassemia
beta-Thalassemia

Source

Identifiers

PMID: 25751242
DOI: 10.1089/gtmb.2014.0310

Genes

HBG2
MYB

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-25751242-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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