Enteroblastic and Hepatoid Colorectal Carcinomas are Aggressive Cancers With a Distinctive Immunophenotype, While Clear Cell Carcinoma Appears to Represent Clear Cell Change in Conventional Colorectal Cancer.

doi:10.1097/PAS.0000000000002555

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Article

Enteroblastic and Hepatoid Colorectal Carcinomas are Aggressive Cancers With a Distinctive Immunophenotype, While Clear Cell Carcinoma Appears to Represent Clear Cell Change in Conventional Colorectal Cancer.

The American journal of surgical pathology - 1 Aug 2026

Khan Fahad, Polydorides Alexandros D, Paulsen John D, Chen Wei, Vazzano Jennifer, Huber Aaron, Papke David, Sharifai Nima, Stashek Kristen, Ruz-Caracuel Ignacio, Allende Daniela, McHugh Kelsey, Shia Jinru, Longacre Teri A, Dhall Deepti, Makhoul Elias, Lee Michael J, Collins Katrina, Ulbright Thomas M, Zhang M Lisa, Westerhoff Maria, Gao Zu-Hua, Matsukuma Karen, Choi Won-Tak, Kakar Sanjay, Chetty Runjan, Nowak Klaudia, Serra Stefano, Zhang Xuchen, Chen Wei, Gonzalez Raul S

Abstract excerpt

Enteroblastic, hepatoid, and clear cell carcinomas are rare subtypes of colorectal carcinoma (CRC) with histologic and immunohistochemical (IHC) overlap. We assessed 37 CRCs that possibly represent these subtypes. Provisional criteria for each subtype, along with case photomicrographs and IHC data, were circulated among the authors to provide diagnostic interpretations. Based on plurality consensus, the...

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PMID: 42012857
DOI: 10.1097/PAS.0000000000002555

Genes

APC
KRAS
TP53

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