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Glioblastoma IDH-wildtype: An integrative review of pathophysiological mechanisms, diagnostic innovations, and emerging therapeutic modalities.

Pathology, research and practice - 1 Jun 2026

Dhingra Pranav, Das Gupta Ghanshyam, Kumar Aman, Patel Preeti, Das Kurmi Balak

Abstract excerpt

The most dangerous and fatal primary brain tumor in adults is glioblastoma multiforme/IDH wild-type glioblastoma (GBM), which is progressive, diffuse, and unresponsive to conventional treatment. Knowledge of the pathophysiology of GBM, genetic mutations, molecular signal transport paths, and tumor-microenvironment interactions is essential in improving clinical outcomes. Proper diagnosis is based on the most...

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PMID: 42000417
DOI: 10.1016/j.prp.2026.156471

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