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Article

A Novel PDZRN3::BRAF Fusion as Potential Driver Mechanism in BAP1-inactivated Melanocytoma.

The American Journal of dermatopathology - 1 Jul 2026

Yu Yanhong, Sabljic Thomas, Capo-Chichi Jose-Mario, Kamil Zaid Saeed

Abstract excerpt

ABSTRACT: BAP1 (BRCA 1-associated protein 1)-inactivated melanocytic tumor (BIMT) is a melanocytic neoplasm characterized histologically by large epithelioid cells and is commonly associated with a conventional nevus component. The defining molecular alteration is inactivation of the BAP1 gene. Initiating mutations in BIMT include BRAF p.V600E, or less commonly RAS mutations and fusions involving RAF1 . In this...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 41996828
DOI: 10.1097/DAD.0000000000003303

Genes

BAP1
BRAF
PDZRN3
PRAME
RAF1
SOX10

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

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