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Article

Melanocytoma With Morphologic Features Reminiscent of BAP-1-Inactivated Melanocytoma but With a Different Molecular Profile.

The American Journal of dermatopathology - 1 Mar 2026

Wright Blair B, Walters Ruth, Googe Paul, Al-Rohil Rami N

Abstract excerpt

ABSTRACT: BRCA1-associated protein (BAP1)-inactivated melanocytoma (BIM) exhibits a unique, biphasic cellular composition. The tumor comprises 2 distinct melanocytic populations: a cytologically bland nevoid of aggregated nests and a more distinctive group of larger, epithelioid melanocytes with prominent eosinophilic cytoplasm. Both cell populations typically test positive for BRAF V600E, with the epithelioid...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 41481331
DOI: 10.1097/DAD.0000000000003209

Genes

BAP1
BRAF
BRCA1
CHEK2

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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Melanocytoma With Morphologic Features Reminiscent of BAP-1-Inactivated Melanocytoma but With a Different Molecular Profile.PMID 41481331Read ↗

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