Article
Beyond typical histology of BAP1-inactivated melanocytoma.
Pathology, research and practice - 1 Jul 2024
Donati Michele, Kazakov Dmitry V
Abstract excerpt
BAP1-inactivated melanocytoma (BIM) is a novel subgroup of melanocytic neoplasm listed in the 5th edition of WHO classification of skin tumor. BIM is characterized by two molecular alterations, including a mitogenic driver mutation (usually BRAF gene) and the loss of function of BAP1, a tumor suppressor gene located on chromosome 3p21, which encodes for BRCA1-associated protein (BAP1). The latter represents a...
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