Article
Dual RAF inhibition outperforms RAF-MEK combinations for suppressing ERK signaling in KRAS mutant cells.
NPJ systems biology and applications - 15 Apr 2026
Imoto Hiroaki, Rauch Nora, Nagasato Ayaka Ichikawa, Okada Mariko, Kolch Walter, Rukhlenko Oleksii S, Kholodenko Boris N
Abstract excerpt
Complex interactions among RAS, RAF, KSR, and MEK isoforms, together with their interplay with clinically used kinase inhibitors, hinder accurate predictions of drug efficacy and the choice of optimal inhibitor combinations. Here, we combine structure-and-rule-based computational modeling with ex...
Topics
- Humans
- Proto-Oncogene Proteins p21(ras)
- Protein Kinase Inhibitors
- raf Kinases
- MAP Kinase Signaling System
- Mutation
- MCF-7 Cells
- Cell Line, Tumor
- Pancreatic Neoplasms
- Mitogen-Activated Protein Kinase Kinases
- Female
- Breast Neoplasms
- Protein Kinases