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Article

Dual RAF inhibition outperforms RAF-MEK combinations for suppressing ERK signaling in KRAS mutant cells.

NPJ systems biology and applications - 15 Apr 2026

Imoto Hiroaki, Rauch Nora, Nagasato Ayaka Ichikawa, Okada Mariko, Kolch Walter, Rukhlenko Oleksii S, Kholodenko Boris N

Abstract excerpt

Complex interactions among RAS, RAF, KSR, and MEK isoforms, together with their interplay with clinically used kinase inhibitors, hinder accurate predictions of drug efficacy and the choice of optimal inhibitor combinations. Here, we combine structure-and-rule-based computational modeling with experiments to systematically study how KSR1 abundance modulates responses to RAF and MEK inhibitors (RAFi and MEKi) in...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 41986383
DOI: 10.1038/s41540-026-00710-6
PMCID: PMC13357827

Genes

KSR1
KRAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

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