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Article

Negative Xpert HPV Test (Cepheid) With Late Amplification Signals: Is There a Clinical Significance? (the PaPCR Study).

Journal of medical virology - 1 Apr 2026

Lemoine Valentin, Legros Romain, Rosec Sylvain, Salaun Camille, Tran-Minoui Adissa, Pilorgé Léa, Vallet Sophie, Le Gourrierec Anne, Alemany Pierre, Marcorelles Pascale, Payan Christopher

Abstract excerpt

Cervical cancer is the fourth most common cancer among women worldwide, with higher prevalence in low-resource countries due to limited access to screening and HPV vaccination. Nucleic acid amplification tests (NAATs) such as Xpert HPV (Cepheid), enable rapid detection of high-risk HPV (HR-HPV) genotypes. However, the clinical significance of weak and late amplification signals (cycle threshold ≥ 38), interpreted...

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Identifiers

PMID: 41982108
DOI: 10.1002/jmv.70915
PMCID: PMC13080410

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 10 Sept 2026.

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