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Article

Whole-exome sequencing increases variant detection compared to karyotyping and CMA in an unselected FGR cohort.

Scientific reports - 14 Apr 2026

Liu Jianzhen, Lin Keng, Mai Zhuowen, Zhang Yongshan, Li Xichong, Meng Xiangrong, Chen Hongzhen

Abstract excerpt

This study aims to systematically evaluate the diagnostic yields of karyotyping, chromosomal microarray analysis (CMA), and whole-exome sequencing (WES) in an unselected cohort of fetuses with fetal growth restriction (FGR). A total of 129 FGR fetuses were included, of which 64 underwent all three genetic tests, enabling a head-to-head comparison. Among these 64 cases, WES detected genetic variants in 25.0%...

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Identifiers

PMID: 41981119
DOI: 10.1038/s41598-026-47909-5
PMCID: PMC13234156

Genes

FGR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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