Detection of chromosomal and gene abnormality with karyotyping, chromosomal microarray analysis and trio-based whole exome sequencing in pregnancies with fetal growth restriction: implications for precise prenatal diagnosis

Abstract excerpt

BACKGROUND: Although extensively investigated, the genetic etiology of fetal growth restriction (FGR) has not been fully understood. Previous studies have shown the potential of karyotyping, chromosomal microarray analysis (CMA) and trio-based WES (trio-WES) in prenatal diagnosis, however, there is little knowledge on the comparative effectiveness of these three prenatal genetic tools. The present study aimed to...

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