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Article

Sarcomatoid Yolk Sac Tumor Harbors Somatic Mutations That Are Otherwise Rare in Testicular Germ Cell Tumors.

The American journal of surgical pathology - 1 May 2022

Acosta Andres M, Al-Obaidy Khaleel I, Sholl Lynette M, Dickson Brendan C, Lindeman Neal I, Hirsch Michelle S, Collins Katrina, Fletcher Christopher D, Idrees Muhammad T

Abstract excerpt

In testicular germ cell tumors (TGCTs), components with nonspecific sarcomatous features that express keratins and glypican 3 are classified as sarcomatoid yolk sac tumor (SYST). SYST is most frequently seen in metastatic sites after chemotherapy. Like so-called "somatic-type" malignancies arising in TGCTs, SYST is markedly resistant to systemic therapy and has a more aggressive clinical course than conventional...

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PMID: 35034041
DOI: 10.1097/PAS.0000000000001865

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