Article
Rethinking mucinous colorectal adenocarcinoma classification: evidence from histopathology and RAS mutations.
Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico - 1 Oct 2026
Wider Dorra, Tounsi Guettiti Haifa, Ardhaoui Monia, Jaballah-Gabteni Amira, Ben Aissa Jihenne, Ben Ayed Ines, Ben Jemii Nadia, Yaiche Hamza, Fehri Emna, Habachi Essia, Maaloul Afifa, Ennaifer Emna, Boubaker Samir
Abstract excerpt
PURPOSE: Mucinous adenocarcinoma (MAC) is a distinct and aggressive subtype of colorectal cancer (CRC), traditionally defined by > 50% mucinous component. However, evidence suggests tumors with lower mucin content may behave similarly. This study investigated clinicopathological and molecular differences between mucinous and non-mucinous CRC, and evaluated the prognostic relevance of the current mucin threshold....
Read the complete abstract on PubMedTopics
- Humans
- Adenocarcinoma, Mucinous
- Colorectal Neoplasms
- Mutation