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Article

Cellular origins and etiological factors for squamous cell carcinoma and related cancer types of the bladder.

The Journal of pathology - 1 Jul 2026

Su Xianbin, Duan Xuehui, Bai Shihao, Su Peipei, Xiao Jing, Shi Yi, Wu Die, Liu Qiang, Tao Kun, Han Bo, Wu Jiao-Xiang, Cheng Sheng, Ding Shengqian, Liu Nian, Chen Yanfang, Ren Jingjuan, Yuan Shuaihu, Shen Qinghong, Yin Zihan, Tian Futong, Liu Mengyao, Yang Guoliang

Abstract excerpt

Squamous cell carcinoma (SCC) of the bladder is a rare disease with poor prognosis and limited molecular profiling. Here we present a multi-layer, comparative investigation on bladder SCC and related cancers, namely pure urothelial carcinoma (UC), UC with squamous differentiation, and bladder adenocarcinoma. The mutational signatures of SCC, UC with squamous differentiation, and pure UC imply similar etiologies,...

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Adenocarcinoma
Biomarkers, Tumor
Carcinoma, Squamous Cell
Mutation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Tumor Microenvironment

Urinary Bladder Neoplasms

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Identifiers

PMID: 41978986
DOI: 10.1002/path.70053

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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